In a skillet, cook ground beef and onion over medium heat until meat is no longer pink; drain.
In a large bowl, mix together the cooked beef and onions, baked beans, ketchup, brown sugar, Worcestershire sauce, mustard, garlic powder, salt, and pepper.
Transfer the mixture to a greased baking dish.
Bake uncovered for 1 hour and 15 minutes, or until bubbly and heated through.